Jon T. Sack

Upregulation of Calbindin in Adult Inhibitory Neurons Reactivates Critical Period Plasticity in Mouse Visual Cortex

A hERG Blocker Facilitates K+ Channel Current by Agonizing Pore Opening while Blocking

The paper investigates how hERG blockers like nifekalant can increase K+ channel current through an agonism-while-blocking mechanism, potentially explaining their safety profile.

Kv2/Kv6.4 heteromeric potassium channels are expressed in spinal motor neurons and localized at C-bouton synapses

The paper identifies a specific Kv2/Kv6.4 channel subtype in spinal motor neurons localized at C-bouton synapses, showing dependence on Kv2 subunits for expression and clustering.

Electrically silent KvS subunits associate with native Kv2 channels in brain and impact diverse properties of channel function

The paper identifies Kv5.1 as a component of native Kv2.1 channels in mouse brain and shows it affects channel function and clustering.

Distinct cellular expression and subcellular localization of Kv2 voltage-gated K+ channel subtypes in dorsal root ganglion neurons conserved between mice and humans

The paper identifies the cellular and subcellular localization of Kv2.1 and Kv2.2 channels in DRG neurons, showing similarities between mice and humans.

A Kv2 inhibitor combination reveals native neuronal conductances consistent with Kv2/KvS heteromers

The paper uses two Kv2 inhibitors to distinguish Kv2/KvS heteromer conductances from Kv2-only channels in neurons.