Robert Zorec

Restoration of (nor)adrenergic-like Ca2+ signalling counteracts age-related motor decline

The paper shows that restoring noradrenergic-like Ca2+ signaling in aged Drosophila improves motor function and lifespan by enhancing metabolic responses.

β-Adrenergic inhibition of exocytotic surface deposition of MHCII molecules in reactive astrocytes is mediated by amisyn

The paper shows that β-adrenergic signaling inhibits MHCII surface deposition in reactive astrocytes via amisyn, reducing exocytosis of lysosome-like vesicles.

GPR27 mediates L-lactate-induced Calcium and cAMP signalling in 3T3 cells

The paper shows that GPR27 mediates L-lactate-induced increases in intracellular calcium and cAMP in 3T3 cells, suggesting L-lactate may act as an endogenous ligand for GPR27.

Norepinephrine stimulates protein synthesis in astrocytes

This study shows norepinephrine stimulates protein synthesis in astrocytes via the mTOR-pS6K pathway, mediated by β-adrenergic receptors and influenced by glycolysis and ATP levels.

Ketamine inhibition of SARS-CoV-2 replication in astrocytes is associated with COVID-19 disease severity in a variant-dependent manner

The paper investigates how ketamine affects SARS-CoV-2 replication in astrocytes and its association with COVID-19 severity, finding variant-dependent inhibition effects.

Plectin Regulates Focal Adhesion Dynamics and Cytoskeletal Organization in Mouse Astrocytes: Implications for Reactive Astrogliosis

Amyloid precursor protein induces reactive astrogliosis

This study shows APP induces reactive astrogliosis in vitro and in vivo by remodeling intermediate filaments, enhancing cytokine production, and activating the IFN pathway.