Matthew Ishahak

Predictive control of human pancreatic cell fate using a digital model of in vitro differentiation

The paper develops a predictive digital model of human pancreatic cell differentiation using single-cell multiomic data to identify regulators and validate their roles in islet fate specification.

Optimizing Post-Transplantation Detection of Subcutaneously Transplanted Islets Using Dithizone Staining

This study evaluates dithizone staining for localizing subcutaneously transplanted islets in mice, showing it reliably identifies insulin-producing β-cells and enables consistent dosing.

Divergent Cell-Type Specific Hypoxia Responses in Human Stem Cell-Derived and Primary Islets

This study compares the hypoxia response of stem cell-derived and primary human islets using single-cell transcriptomics, revealing divergent metabolic and apoptotic responses.

Coxsackievirus B infection invokes unique cell-type specific responses in primary human pancreatic islets

This study investigates how Coxsackievirus B (CVB) infection affects different cell types in human pancreatic islets using single-cell RNA sequencing, revealing cell-specific transcriptional and functional responses.

Modeling glioblastoma tumor progression via CRISPR-engineered brain organoids

This study develops CRISPR-engineered glioblastoma organoids to model tumor progression, revealing transcriptional and spatial changes in neurodevelopmental gene networks.