Sarah E. Gale

The paper develops a predictive digital model of human pancreatic cell differentiation using single-cell multiomic data to identify regulators and validate their roles in islet fate specification.

The paper shows that depolymerizing F-actin with latrunculin A during early differentiation improves hPSC-derived islet maturation and function by altering signaling pathways and lineage specification.

This study shows that the IFIH1 E627* variant protects human pancreatic islets from stress-induced dysfunction by reducing immune responses and apoptosis.

This study uses magnetic sorting to enrich human stem cell-derived islets for CD49a, improving β-cell identity and function for diabetes therapy.