Hubert Ming Tse

This study shows that Brca1 heterozygosity causes hepatic steatosis in both male and female mice on a high-fat diet, despite sex differences in systemic metabolic outcomes.

This study shows that the IFIH1 E627* variant protects human pancreatic islets from stress-induced dysfunction by reducing immune responses and apoptosis.

This study identifies sex-specific islet responses to inflammation and shows that estrogen reduces inflammatory signaling and promotes immune tolerance in beta cells, contributing to sex differences in type 1 diabetes susceptibility.

This study investigates how Coxsackievirus B (CVB) infection affects different cell types in human pancreatic islets using single-cell RNA sequencing, revealing cell-specific transcriptional and functional responses.

This study shows that surface roughness of electrospun fibers modulates macrophage phenotype by altering cytokine release and CD206/CD80 expression in vitro and in vivo.