Noyonika Mukherjee

The paper develops a predictive digital model of human pancreatic cell differentiation using single-cell multiomic data to identify regulators and validate their roles in islet fate specification.

This study shows RIPK1 promotes beta-cell death in autoimmune diabetes by affecting gene expression and kinase signaling, suggesting it as a therapeutic target.

This study shows that the IFIH1 E627* variant protects human pancreatic islets from stress-induced dysfunction by reducing immune responses and apoptosis.

This paper identifies VDAC1 as the target of SW016789, a hypersecretion inducer, and shows it causes distinct transcriptomic changes in beta-cells compared to ER stress.

This study uses magnetic sorting to enrich human stem cell-derived islets for CD49a, improving β-cell identity and function for diabetes therapy.