Flexibly-oriented double Cdc45-MCM-GINS intermediates during eukaryotic replicative helicase maturation
Lu Liu, Yue Zhang, Jingjing Zhang, Jianhua Wang, Qinhong Cao, Zhen Li, Judith L. Campbell, Meng‐Qiu Dong, Huiqiang Lou
This study identifies d-CMG intermediates during MCM helicase maturation, showing they are structurally distinct from MCM DHs and functionally immature compared to RPCs.
bioRxiv · Aug 9, 2018 · PreprintMolecular Biology