Huiqiang Lou

This study identifies two distinct RNA-guided transposition pathways used by IS110 transposons, resolving prior inconsistencies in their mechanism.

The paper shows that overexpression of WHI7 bypasses the need for Mec1 and Rad53 in Saccharomyces cerevisiae, revealing a transcription-independent role in delaying G1/S transition during replication stress.

The paper identifies Mck1 as a key S-phase checkpoint effector that regulates dNTP homeostasis by modulating RNR and HUG1 expression in response to replication threats.

The paper identifies Cul4-Ddb1 ubiquitin ligases as regulators of Esco2-mediated sister chromatid cohesion through Smc3 acetylation in human cells.

This study identifies d-CMG intermediates during MCM helicase maturation, showing they are structurally distinct from MCM DHs and functionally immature compared to RPCs.