Katharine E McCann

This study investigates the impact of early locus coeruleus lesions in TgF344-AD rats and finds that LC lesions and AD genotype rarely interact to worsen deficits or neuropathology.

The paper investigates how CA2 neuronal activity influences social behavior after acute social stress in mice, finding that CA2 inhibition increases social avoidance and reduces submissive defense behaviors.

This study identifies entorhinal cortex PV interneuron vulnerability to hAPP as a driver of hyperexcitability and tau pathology in Alzheimer's Disease.

This study shows that dopamine β-hydroxylase knockout in mice alters innate responses to predator odor, with reduced defensive burying and increased grooming, suggesting NE and DA balance regulates behavioral responses.

This study uses DSP-4 to model early LC-NE system changes in AD and PD, showing axon damage, neuroinflammation, and behavioral changes without LC cell death.

This study examines age-related changes in locus coeruleus firing in a transgenic rat model of Alzheimer's disease, finding age-dependent hypoactivity and hyperactivity in response to stimuli.

The paper investigates how norepinephrine and dopamine influence distinct repetitive behaviors in mice exposed to novel odorants, showing differential effects on digging and grooming.

This study investigates the effects of hyperphosphorylated tau on AD-like neuropathology and behavior in a rat model using viral delivery of human tau.

This study investigates the distinct roles of norepinephrine and galanin in stress-induced anxiety-like behavior using genetic and pharmacological approaches in mice.

This study measures binding affinities of oxytocin, vasopressin, and Manning compound at oxytocin and V1a receptors in Syrian hamster brains, revealing species-specific receptor promiscuity.