Bert Klebl

PDE3A-SLFN12 Molecular Glues Target Multiple KIT D816V Cell Types in Preclinical Models of Mast Cell Malignancies

This paper identifies PDE3A-SLFN12 molecular glues as a novel therapeutic target for KIT D816V-driven mast cell malignancies, showing their efficacy in killing multiple KIT D816V cell types and synergy with tyrosine kinase inhibitors.

Expression of recombinant human glutamylating TTLLs in human cells leads to differential tubulin glutamylation patterns, with only TTLL6 disrupting microtubule dynamics

This study shows that TTLL6 disrupts microtubule dynamics and that LDC10 inhibits TTLL activity and reverses TTLL6's effects.

Enabling antibiotic research: towards selective peptide deformylase inhibitors

This study identifies two selective peptide deformylase inhibitors with antibacterial activity and low cytotoxicity, validated through in vitro and in vivo assays.

Glucose Metabolism Controls Oxidative Burst and Lipid Mediator Production in Neutrophils upon Microbial Challenge

This study shows that glucose uptake via GLUT1/3 is essential for neutrophil oxidative burst and lipid mediator production during microbial infection.