T cell responsiveness to IL-10 defines the immunomodulatory effect of costimulation blockade via anti-CD154 and impacts transplant survival
Marcos Iglesias, Darrel Bibicheff, Alexander Komin, Maria Chicco, Samantha R. Guinn, Brendan Foley, Giorgio Raimondi
This study shows that T cell responsiveness to IL-10 determines the effectiveness of costimulation blockade therapy in transplant models, impacting graft survival.
bioRxiv · Jun 12, 2024 · PreprintImmunology