Sen-Lin Lai

The paper identifies Engrailed and Vnd as spatial transcription factors that act combinatorially in a brief competence window to specify the identity of neuroblast 7-1 in Drosophila embryos.

The paper uses single nuclei RNA sequencing to analyze transcriptional diversity of T2 neuroblast-derived neurons and glia in Drosophila, identifying clusters and transcription factor codes for neuron subtypes in the central complex.

The paper uses scRNA-seq to analyze Drosophila embryos and neuroblast lineages, identifying gene expression patterns and lineage-specific markers.

The paper maps the developmental origin of interneurons in Drosophila and shows how lineage and temporal identity shape synaptic connectivity and circuit formation.

The paper shows that a temporal identity window in Drosophila neuroblast lineage generates alternating cardinal motor neuron subtypes through the Kr/Pdm pathway.

The paper shows that repressor-decay timers are more robust than activator-relay timers in Drosophila neuroblast lineages, supporting a repressor-decay mechanism for temporal patterning.