Chris Q. Doe

The paper shows that cell body clustering of Drosophila MDNs enables gap junction-mediated synchronous activity essential for backward walking.

The paper identifies Engrailed and Vnd as spatial transcription factors that act combinatorially in a brief competence window to specify the identity of neuroblast 7-1 in Drosophila embryos.

This study shows that Hunchback (Hb) in Drosophila larval MDN neurons restricts axon outgrowth, synapse formation, and backward locomotion by maintaining mature neuronal identity.

The paper identifies Castor as a temporal transcription factor in Drosophila that specifies early-born central complex neuron identities.

This study shows that prolonged Hunchback expression in Drosophila NB5-2 progenitors alters interneuron molecular identity, morphology, and presynapse targeting, affecting proprioceptive behavior.

The paper identifies a regulatory logic in progenitors that generates functionally related neuronal subtypes, showing its conservation across species.

The paper shows that Seven-up (Svp) specifies adult central complex neuron identity and initiates neuroblast decommissioning in Drosophila.

The paper uses single nuclei RNA sequencing to analyze transcriptional diversity of T2 neuroblast-derived neurons and glia in Drosophila, identifying clusters and transcription factor codes for neuron subtypes in the central complex.

The paper shows that homeodomain transcription factors (HDTFs) hierarchically specify neuronal diversity and synaptic connectivity in Drosophila lamina neurons.

The paper shows Notch signaling differentially specifies L4 and L5 Drosophila lamina neuron fates by modulating Bsh's chromatin accessibility and gene activation.

This study shows that Imp promotes exit from quiescence in Drosophila type II neuroblasts, independent of Syncrip, and relates to its role in promoting proliferation.

The paper investigates how presynaptic contact and activity opposingly regulate postsynaptic dendrite outgrowth during neural circuit development in Drosophila.

The paper uses scRNA-seq to analyze Drosophila embryos and neuroblast lineages, identifying gene expression patterns and lineage-specific markers.

This study shows Hunchback activates Bicoid in post-mitotic Pair1 neurons to regulate synapse number and circuit function in Drosophila larvae.

The paper shows that mechanosensory input during Drosophila circuit formation regulates patterned spontaneous network activity (PaSNA), which is essential for larval locomotor behavior.

The paper shows that the MDN-Pair1 neural circuit persists through metamorphosis in Drosophila and maintains similar locomotor function in larvae and adults.

The paper identifies astrocytes as essential for closing the critical period of motor circuit plasticity in Drosophila by regulating dendrite morphology and locomotor behavior through Neuroligin-Neurexin signaling.

The paper maps the developmental origin of interneurons in Drosophila and shows how lineage and temporal identity shape synaptic connectivity and circuit formation.

The paper investigates how synaptic connections in Drosophila are formed through partner-derived cues, global positional cues, and synaptic activity, showing that all three contribute to proper circuit assembly.

The paper shows that a temporal identity window in Drosophila neuroblast lineage generates alternating cardinal motor neuron subtypes through the Kr/Pdm pathway.

The paper constructs a Drosophila larval connectome linking proprioceptors, premotor neurons, and motor neurons to explain how distinct motor behaviors arise from shared neural circuits.

The paper investigates how axon guidance cues determine subcellular synapse specificity in Drosophila neurons, showing that these cues, not distinct dendritic domains, dictate synaptic connections.

This study shows that intrinsic temporal identity, determined by the Hunchback transcription factor, dictates axon and dendrite targeting in Drosophila motor neurons, overriding birth order.

The paper shows that developmental origin shapes connectivity and function in Drosophila navigation circuit neurons, with Eyeless/Pax6 regulating their number and navigation ability.

The paper shows that repressor-decay timers are more robust than activator-relay timers in Drosophila neuroblast lineages, supporting a repressor-decay mechanism for temporal patterning.

The paper identifies how spatial and temporal cues integrate in Drosophila neuroblasts through chromatin landscapes to generate neuronal diversity.

The paper identifies a command-like descending neuron that induces backward locomotion and inhibits forward locomotion in larvae and adults.

This study identifies the origin and developmental contribution of type II neuroblasts in Drosophila embryos, showing they generate neurons that contribute to the adult central complex.