Respiratory mucosal administration of DNA aptamer nanomaterials protects against antigenically diverse SARS-CoV-2 variants
Michael R. D’Agostino, Jiuxing Li, Zijie Zhang, Jimmy Gu, Art Marzok, Jann Catherine Ang, Katherine E. Bujold, Sam Afkhami, Xiaohu Xia, Yingfu Li, Matthew S. Miller
This study shows that DNA aptamer nanomaterials can protect against diverse SARS-CoV-2 variants through respiratory mucosal administration, offering broad neutralization and superior protection compared to monoclonal antibodies.
bioRxiv · May 31, 2024 · PreprintImmunology