Author

Sam Afkhami

Michael G. DeGroote Institute for Infectious Disease ResearchORCID 0009-0000-2540-2012Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Art MarzokiD· 3 shared Jann Catherine Ang· 3 shared Matthew S. MilleriD· 3 shared Jonathan Mapletoft· 2 shared Michael R. D’AgostinoiD· 2 shared Vithushan SurendraniD· 2 shared Yona TuggiD· 2 shared Ali ZhangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersImmunology

Art MarzokORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Acute Viral Infection Accelerates Neurodegeneration in a Mouse Model of ALS

Art Marzok, Jonathan Mapletoft, Imran Ahmed, Braeden Cowbrough, Daniel B. Celeste, Michael R. D’Agostino, Jann Catherine Ang, Andrew Chen, Vithushan Surendran, Yona Tugg, Hahn Li, Karena Wong, Anna Dvorkin‐Gheva, Ali Zhang, Hannah D. Stacey, , Matthew S. Miller

Acute viral infection accelerates ALS progression in SOD1G93A mice by inducing gliosis and metabolic dysregulation, which can be mitigated by anti-inflammatory or antiviral treatments.

Nature Communications · Aug 29, 2026Peer-reviewedImmunology

Senataxin is required for optimal class switch recombination to the immunoglobulin A isotype

Vithushan Surendran, Jonathan Mapletoft, Peter YF. Zeng, Julia Avolio, Sam Afkhami, Joshua J.C. McGrath, Andrew T. Chen, Art Marzok, Jann Catherine Ang, Kyle Amaral, Yona Tugg, Martin R. Stämpfli, Matthew S. Miller

This study shows that senataxin deficiency impairs class switch recombination to IgA in vitro, reduces IgA response to infection, and decreases IgA repertoire diversity in vivo.

bioRxiv · Sep 23, 2025 · PreprintImmunology

Respiratory mucosal administration of DNA aptamer nanomaterials protects against antigenically diverse SARS-CoV-2 variants

Michael R. D’Agostino, Jiuxing Li, Zijie Zhang, Jimmy Gu, Art Marzok, Jann Catherine Ang, Katherine E. Bujold, Sam Afkhami, Xiaohu Xia, Yingfu Li, Matthew S. Miller

This study shows that DNA aptamer nanomaterials can protect against diverse SARS-CoV-2 variants through respiratory mucosal administration, offering broad neutralization and superior protection compared to monoclonal antibodies.

bioRxiv · May 31, 2024 · PreprintImmunology