Christopher T. Rentsch

Genotype-predicted drug response phenotypes and their co-occurrence with dispensed medicines among 738,531 participants in the UK Our Future Health study

The paper assesses the co-occurrence of actionable pharmacogenomic phenotypes with dispensed medicines in 738,531 UK participants, finding 36.8% had gene-matched medications.

Shared Genetic Architecture and Neurobiological Pathways of Problematic Alcohol Use and Anxiety Disorders

This study identifies shared genetic and neurobiological pathways between problematic alcohol use and anxiety disorders using genomic analyses.

Genetic and Proteomic Investigation of the Smoking-Parkinson Disease Association

This study investigates the causal relationship between smoking and Parkinson's disease using genetic and proteomic data, identifying shared biological pathways and potential therapeutic targets.

Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations

The paper investigates genetic and neural overlaps between alcohol use disorder and BMI, finding polygenic overlap despite minimal genetic correlation and identifying shared brain regions involved in executive function and reward.

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brain

This study performs a cross-ancestry meta-analysis of opioid use disorder, identifying 14 loci, including 12 novel ones, and finding significant genetic correlations with psychiatric and neurological traits.

The relationship between glycaemia, cognitive function, structural brain outcomes and dementia: A Mendelian randomization study in the UK Biobank

This paper uses Mendelian randomization to examine causal relationships between glycaemia, cognitive function, brain structure, and dementia in UK Biobank data, finding little evidence of causal associations.

GWAS including 82,707 subjects identifies functional coding variant in OPRM1 gene associated with opioid use disorder