Impact of PIK3CA gain and PTEN loss on mantle cell lymphoma biology and sensitivity to targeted therapies
Nardjas Bettazová, Jana Seňavová, Kristýna Kupcová, Dana Sovilj, Anežka Rajmonová, Ladislav Anděra, Karla Svobodová, Adéla Berková, Vaclav Herman, Zuzana Zemanová, Lenka Daumová, Alexandra Dolníková, Richard Eric Davis, Marek Trněný, Pavel Klener, Ondřej Havránek
This study investigates how PIK3CA gain and PTEN loss affect MCL biology and drug response, finding reduced BCR dependence and increased therapy resistance.
Blood Advances · Aug 19, 2024Peer-reviewedCancer Biology