Haobo Wang

This study identifies PSA as an inhibitory auxiliary subunit of VRACs, showing its regulatory role is independent of aminopeptidase activity.

The paper investigates how ESM-2, a protein language model, predicts protein contacts by analyzing coevolving residue statistics and local sequence context.

This paper introduces sgGOLDFISH, a method for single-nucleotide sensitivity in direct hybridization genome imaging, and demonstrates its application in identifying and localizing point mutations in progeroid fibroblasts.

The paper introduces a spectral clustering model to identify protein sectors from sequence coevolution data, revealing networks of residues not captured by structural contacts.

This paper introduces a spectral regularizer to disentangle entropy from coevolution in sequence models, improving interpretability and reducing overfitting in contact map inference.

This study evaluates how well generative sequence models capture structural and fitness patterns from protein families, finding that structural and fitness information are not necessarily correlated.