Sophia V. Derdak

Spatial single-cell interactome and niche-specific molecular signatures in alcohol-related liver disease

The paper uses spatial transcriptomics and single-cell data to identify niche-specific molecular signatures and signaling pathways in ALD cirrhosis, highlighting potential therapeutic targets.

Nanopore sequencing unveils the complexity of the cold-activated murine brown adipose tissue transcriptome

The paper benchmarks ONT long-read sequencing against Illumina short-read sequencing in cold-activated BAT, finding ONT superior for transcriptome reassembly but less powerful for differential expression analysis.

The ADAR1 editome reveals drivers of editing-specificity for ADAR1-isoforms

The paper investigates ADAR1 isoform-specific editing by analyzing binding and editing patterns in human and mouse cells, revealing that cytoplasmic localization drives editing specificity.

New genes involved in Angelman syndrome-like: expanding the genetic spectrum

The paper identifies new genetic variants in patients with Angelman syndrome-like features, expanding the known genetic spectrum and highlighting genetic heterogeneity.