Author

Jianzhong Hu

Amgen (United States)ORCID 0000-0002-7548-5802Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alex Golkar· 1 shared Alison Inglis· 1 shared Amine SadokiD· 1 shared Bo ZhouiD· 1 shared Jaeki MiniD· 1 shared Kate Smither· 1 shared Kaylee ChoiiD· 1 shared Kelvin Frank ChoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Alex Golkar

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1 paper

Recent·Most cited

Reprogramming VHL with molecular glues enables selective degradation of caspase-2

Jianzhong Hu, Weixian Deng, Shu Ou, Alex Golkar, Alison Inglis, Kate Smither, Shiqian Li, Kui Chen, Kelvin Frank Cho, Sung Jun Bae, Stephan Zech, Kaylee Choi, Willem den Besten, Stephanie Voß, Olivier Bedel, , Jaeki Min

This study develops VHL molecular glues that selectively degrade caspase-2, expanding the substrate range of VHL-based degraders and providing tools to study caspase-2's role in apoptosis and stress.

bioRxiv · Aug 17, 2026 · PreprintBiochemistry