Weixian Deng

This study develops VHL molecular glues that selectively degrade caspase-2, expanding the substrate range of VHL-based degraders and providing tools to study caspase-2's role in apoptosis and stress.

The paper investigates PABPC1's role in alternative polyadenylation during B cell development, finding it primarily shortens and downregulates its targets in a context-dependent manner.

This paper introduces LYMTACs, small molecules that use lysosomal membrane proteins to target and degrade membrane proteins, showing effectiveness against KRASG12D.

The paper identifies CRTC1-proximal proteins in neurons and reveals cooperative chromatin binding between CREB1 and CRTC1 with MEF2C and RFX3 during synaptic activity.

The paper discovers a VHL molecular glue degrader of GEMIN3 using Picowell RNA-seq screening, showing how it targets GEMIN3 for degradation through ternary complex formation.

The paper shows that neuronal activity reduces nuclear PDCD4 levels via proteasome-mediated degradation, which regulates activity-dependent transcription.