Author

Olivier Bedel

Amgen (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1

Frequent Co-Authors

Alex Golkar· 2 shared Bo ZhouiD· 2 shared Jaeki MiniD· 2 shared Patrick Ryan PottsiD· 2 shared Shiqian LiiD· 2 shared Shu OuiD· 2 shared Stephanie VoßiD· 2 shared Weixian DengiD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Alex Golkar

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Reprogramming VHL with molecular glues enables selective degradation of caspase-2

Jianzhong Hu, Weixian Deng, Shu Ou, Alex Golkar, Alison Inglis, Kate Smither, Shiqian Li, Kui Chen, Kelvin Frank Cho, Sung Jun Bae, Stephan Zech, Kaylee Choi, Willem den Besten, Stephanie Voß, Olivier Bedel, , Jaeki Min

This study develops VHL molecular glues that selectively degrade caspase-2, expanding the substrate range of VHL-based degraders and providing tools to study caspase-2's role in apoptosis and stress.

bioRxiv · Aug 17, 2026 · PreprintBiochemistry

Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq

Jonathan W. Bushman, Weixian Deng, Kusal T. G. Samarasinghe, Han‐Yuan Liu, Shiqian Li, Amit Vaish, Alex Golkar, Shu Ou, Jinwoo Ahn, Rajesh K. Harijan, Han Han, Tomas Duffy, Elliot Imler, Judy Qiju Wu, Reneé Rawson, , Patrick Ryan Potts

The paper discovers a VHL molecular glue degrader of GEMIN3 using Picowell RNA-seq screening, showing how it targets GEMIN3 for degradation through ternary complex formation.

bioRxiv · Mar 19, 2025 · PreprintBiochemistry