Author

Sara Sanz Juste

The University of Texas MD Anderson Cancer CenterORCID 0000-0002-7554-1114Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 1 Organism:Drosophila· 1

Frequent Co-Authors

Víctor López Del AmoiD· 2 shared Blaine BartholomewiD· 1 shared Christina NguyeniD· 1 shared Emily M. OkamotoiD· 1 shared Jeison García· 1 shared Karissa Beauchemin· 1 shared Shagun ShuklaiD· 1 shared Somnath PauliD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersGenetics

Víctor López Del AmoORCID

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3 papers

Recent·Most cited

Conformational switching of Arp5 subunit differentially regulates INO80 chromatin remodeling

Shagun Shukla, Somnath Paul, Jeison García, Yuan Zhong, Sara Sanz Juste, Karissa Beauchemin, Blaine Bartholomew

This study identifies two distinct binding mechanisms of the Arp5 subunit in the INO80 chromatin remodeler, showing their differential roles in nucleosome positioning and dimer exchange.

Nucleic Acids Research · Dec 16, 2024Peer-reviewedBiochemistry

Next-generation CRISPR gene-drive systems using Cas12a nuclease

Sara Sanz Juste, Emily M. Okamoto, Christina Nguyen, Xuechun Feng, Víctor López Del Amo

This paper presents a temperature-regulated Cas12a-based gene-drive system and demonstrates double gene drives using Cas9 and Cas12a to spread two engineered alleles.

Nature Communications · Oct 12, 2023Peer-reviewedGenetics

A nickase Cas9 gene-drive system promotes super-Mendelian inheritance in Drosophila

Víctor López Del Amo, Sara Sanz Juste, Valentino Matteo Gantz

This paper introduces a nickase Cas9 gene-drive system in Drosophila that achieves super-Mendelian inheritance through staggered DNA nicks and efficient allelic conversion.

Cell Reports · May 1, 2022Peer-reviewedMolecular Biology