Víctor López Del Amo

Self-limiting population suppression gene drive in the West Nile vector mosquito, Culex quinquefasciatus

This paper describes a CRISPR-based gene drive targeting the doublesex gene in Culex mosquitoes to suppress populations through male-biased propagation and sterile intersexes.

Next-generation CRISPR gene-drive systems using Cas12a nuclease

This paper presents a temperature-regulated Cas12a-based gene-drive system and demonstrates double gene drives using Cas9 and Cas12a to spread two engineered alleles.

A nickase Cas9 gene-drive system promotes super-Mendelian inheritance in Drosophila

This paper introduces a nickase Cas9 gene-drive system in Drosophila that achieves super-Mendelian inheritance through staggered DNA nicks and efficient allelic conversion.

Optimized CRISPR tools and site-directed transgenesis in Culex quinquefasciatus mosquitoes for gene drive development.

The paper develops CRISPR tools and site-directed transgenesis in Culex mosquitoes to improve gene drive systems for disease control.

Small-molecule control of super-Mendelian inheritance in gene drives

The paper describes a gene-drive system in Drosophila controlled by an engineered Cas9 and a synthetic small molecule to enable chemical control of inheritance.

Split-gene drive system provides flexible application for safe laboratory investigation and potential field deployment

The paper introduces a split-gene-drive system that enhances safety and flexibility in CRISPR-based gene drive applications through trans-complementation.