Valentino Matteo Gantz

This study shows that sequence mismatches between gene-drive and target-site flanking regions reduce homing efficiency in Culex quinquefasciatus by up to 54%.

This paper presents a chromosome-level genome assembly and transcriptomes for Megaselia abdita, revealing genomic and expression similarities and differences with Drosophila melanogaster.

This paper describes a CRISPR-based gene drive targeting the doublesex gene in Culex mosquitoes to suppress populations through male-biased propagation and sterile intersexes.

This study demonstrates CRISPR-based gene drives in Culex quinquefasciatus, showing biased inheritance of transgenes with modest efficiency.

The paper identifies key parameters for efficient AG gene conversion in rats and mice by testing promoter-target site pairs and Cas9 configurations.

This paper introduces a nickase Cas9 gene-drive system in Drosophila that achieves super-Mendelian inheritance through staggered DNA nicks and efficient allelic conversion.

This study shows that meiotic Cas9 expression can mediate genotype conversion in both male and female mouse germlines, but low Cas9 levels limit efficiency.

The paper evaluates CRISPR-mediated knock-outs of pigmentation genes in Culex quinquefasciatus to identify viable targets for genetic engineering and conservation applications.

The paper develops CRISPR tools and site-directed transgenesis in Culex mosquitoes to improve gene drive systems for disease control.

This paper develops a gene-drive rescue system in Anopheles stephensi to efficiently modify mosquito populations for malaria control.

The paper describes a gene-drive system in Drosophila controlled by an engineered Cas9 and a synthetic small molecule to enable chemical control of inheritance.

The paper introduces a split-gene-drive system that enhances safety and flexibility in CRISPR-based gene drive applications through trans-complementation.

This study evaluates a split homing gene drive in Drosophila to simultaneously target two genes, showing high disruption efficiency but also resistance allele accumulation.

This paper demonstrates that CRISPR/Cas9 can mediate super-Mendelian inheritance in female mouse germline through homology-directed repair.