Rikeish R. Muralitharan

Rare pathogenic variants in G-protein coupled receptor genes involved in gut-to-host communication are associated with cardiovascular disease risk

The paper identifies rare pathogenic variants in GPCR genes linked to gut-to-host communication and finds they are associated with increased cardiovascular disease risk in humans.

Gut bacteria translocation to the brain after ischaemic stroke occurs via the sympathetic nervous system

The paper shows that gut bacteria translocate to the brain after stroke via the sympathetic nervous system, worsening motor function in mice.

Dietary fibre controls blood pressure and cardiovascular risk by lowering large intestinal pH and activating the proton-sensing receptor GPR65

This study shows dietary fiber lowers blood pressure by reducing large intestinal pH and activating GPR65 in CD8+ T cells, which reduces inflammation and hypertension-related damage.