Author

Seiichiro Sakai

Japan Agency for Medical Research and DevelopmentORCID 0000-0002-7591-1621Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

Hideya KawajiiD· 2 shared Ito KawakamiiD· 2 shared Jun TsuyamaiD· 2 shared Takashi ShichitaiD· 2 shared Yuichiro HaraiD· 2 shared Ayaka Nakamura· 1 shared Eri Tanaka· 1 shared K. AbeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPathology

Hideya KawajiORCID

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2 papers

Recent·Most cited

PathologyNaturePeer-reviewedMay 13, 2026

Sustaining microglial reparative function enhances stroke recovery

Jun Tsuyama, Seiichiro Sakai, Kumiko Kurabayashi…·Takashi Shichita

This study identifies ZFP384 as a regulator that impairs microglial reparative function after stroke, and shows that targeting ZFP384 enhances recovery even in the chronic phase.

16 citationstop 1%

mousebulk RNA-seq

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NeurosciencebioRxivPreprintMay 12, 2025

Anti-amyloid beta therapy resolves stroke recovery impairment caused by Alzheimer's disease

Seiichiro Sakai, Kento Otani, Jun Tsuyama…·Takashi Shichita

This study shows that anti-amyloid beta therapy improves stroke recovery in the presence of cerebral amyloid beta accumulation by resolving myeloid immunity impairment.

DOI 10.1101/2025.05.12.653388

mousehuman

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