Yuichiro Hara

Dual Developmental Origins and Activity-dependent Specification of Mammalian Subplate Neurons

The paper identifies two distinct developmental origins of subplate neurons in mammals through comparative single-cell and spatial transcriptomics across amniotes.

Sustaining microglial reparative function enhances stroke recovery

This study identifies ZFP384 as a regulator that impairs microglial reparative function after stroke, and shows that targeting ZFP384 enhances recovery even in the chronic phase.

Anti-amyloid beta therapy resolves stroke recovery impairment caused by Alzheimer's disease

This study shows that anti-amyloid beta therapy improves stroke recovery in the presence of cerebral amyloid beta accumulation by resolving myeloid immunity impairment.

Spatial transcriptome of developmental mouse brain reveals temporal dynamics of gene expressions and heterogeneity of the claustrum

This study uses spatial transcriptomics to analyze the developing mouse brain, identifying novel molecular markers and revealing heterogeneity in the claustrum.

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation

This study identifies ELOF1 as a factor that directs CRL4CSA to ubiquitylate RNAPII at K1268, facilitating TCR and protecting CSB-deficient cells from transcription-replication collisions.

Inference of a genome-wide protein-coding gene set of the inshore hagfish Eptatretus burgeri

The paper reconstructs a high-coverage coding gene set for the inshore hagfish Eptatretus burgeri using genome sequencing and RNA-seq data.