Benjamin I. Laufer

Predictive in vitro profiling of LNP-induced innate immune response using an iPSC-derived monocyte model

This study develops an iPSC-derived monocyte model to predict LNP-induced innate immune responses, showing improved reproducibility and correlation with in vivo cytokine responses.

Integrated Cross-Disease Atlas of Human And Mouse Astrocytes Reveals Heterogeneity and Conservation of Astrocyte Subtypes in Neurodegeneration

The paper constructs an integrated atlas of astrocytes from human and mouse neurodegenerative disease models, identifying conserved and divergent subtypes across species.

Epigenomic signature of major congenital heart defects in newborns with Down syndrome

The paper identifies sex-specific DNA methylation differences in newborns with Down syndrome and major congenital heart defects compared to those without defects.

Multi-omic brain and behavioral correlates of cell-free fetal DNA methylation in macaque maternal obesity models

The paper identifies methylation changes in cell-free fetal DNA linked to maternal obesity and correlates them with infant brain and behavioral outcomes in macaques.

Impact of exposures to persistent endocrine disrupting compounds on the sperm methylome in regions associated with neurodevelopmental disorders

This study examines the association between exposure to DDE and DNA methylation patterns in sperm, finding enriched ASD risk genes and neurodevelopmental pathways.

Genome-Wide DNA Methylation Profiles of Neurodevelopmental Disorder Genes in Mouse Placenta and Fetal Brain Following Prenatal Exposure to Polychlorinated Biphenyls

This study examines DNA methylation changes in mouse placenta and fetal brain after prenatal PCB exposure, finding shared differentially methylated regions linked to neurodevelopmental disorders.

Long-term effects of wildfire smoke exposure during early-life on the nasal epigenome in rhesus macaques

This study identifies long-term epigenetic changes in rhesus macaques exposed to wildfire smoke during early life, showing methylation differences and gene expression changes linked to immune and nervous system processes.

Stable DNMT3L Overexpression in SH-SY5Y Neurons Recreates a Facet of the Genome-Wide Down Syndrome DNA Methylation Signature

This study overexpresses DNMT3L in SH-SY5Y neurons and shows it recreates aspects of the DS DNA methylation signature through hypermethylation and hypomethylation of specific genomic regions.

Cord blood DNA methylome in newborns later diagnosed with autism spectrum disorder reflects early dysregulation of neurodevelopmental and X-linked genes

The paper identifies DNA methylation differences in cord blood samples from newborns later diagnosed with ASD, revealing sex-specific epigenomic signatures linked to neurodevelopmental and X-linked genes.

Low-Pass Whole Genome Bisulfite Sequencing of Neonatal Dried Blood Spots Identifies a Role for RUNX1 in Down Syndrome DNA Methylation Profiles

The paper uses low-pass whole genome bisulfite sequencing on neonatal dried blood spots to identify DNA methylation differences in Down syndrome, highlighting RUNX1 hypermethylation and its association with congenital heart disease.

Imprinting effects of UBE3A loss on synaptic gene networks and Wnt signaling pathways

This paper investigates the molecular impacts of UBE3A loss in a novel rat model of Angelman syndrome using systems biology approaches, revealing epigenetic network interactions between maternal and paternal transcripts.

Epigenomic convergence of genetic and immune risk factors in neurodevelopmental disorder cortex

The paper identifies epigenomic signatures in NDD cortex samples, revealing shared regulatory functions and enrichment for genetic risk factors across different NDD types.

Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disease insights

The paper identifies 3,152 differentially methylated regions in DS brain tissue using WGBS, revealing hypermethylation in key biological pathways and cross-tissue concordance for hypermethylated regions.

Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex

This study identifies Snord116-dependent diurnal DNA methylation rhythms in mouse cortex and shows their disruption in Prader-Willi syndrome.

Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches

The paper investigates how augmented maternal care affects DNA methylation, gene expression, and miRNA levels in the developing hypothalamus, identifying genes linked to stress resilience.