Knockdown of the long isoform of the prolactin receptor selectively targets pathogenic immune cells and averts lupus nephritis
Kory Hamane, Zunsong Hu, João Rodrigues Lima-Júnior, Adeleh Taghi Khani, Anil Kumar, Ashly Sanchez Ortiz, Xinying Guo, Da Hae Jung, Hanjun Qin, Shu Tao, I. Sanz, Eric Meffre, Katherine Marzan, Jean Louise Koff, Mary Y. Lorenson, , Srividya Swaminathan
This study shows that knocking down the long isoform of the prolactin receptor reduces pathogenic immune cells and prevents lupus nephritis in SLE-prone mice.
bioRxiv · Mar 16, 2026 · PreprintImmunology