Eric Meffre

This study shows that knocking down the long isoform of the prolactin receptor reduces pathogenic immune cells and prevents lupus nephritis in SLE-prone mice.

The paper shows EBV infects and reprograms autoreactive B cells into antigen-presenting cells in MS, driving pathogenic T cell responses.

This study identifies senescent activated naive B cells in ACPA+ individuals that promote anti-citrullinated antigen T cell responses and drive progression to clinical RA.

This study identifies de novo LYN variants causing constitutive Lyn kinase activation, leading to neutrophilic vasculitis and liver fibrosis, and shows therapeutic response to Src kinase inhibitors.

This paper develops a non-viral CRISPR-Cas9 system for precise genome editing in human T cells, enabling therapeutic reprogramming of cell function and specificity.