Rebecca E. Steiner

Chaperoning the chaperones: Proteomic analysis of the SMN complex reveals conserved and etiologic connections to the proteostasis network

The paper identifies SMN complex binding partners and reveals conserved connections to chaperone systems, linking chaperone dysfunction to ALS and SMA.

Dysregulation of innate immune signaling in animal models of Spinal Muscular Atrophy

This study identifies hyperactivation of innate immune signaling as a consequence of SMN depletion in Drosophila SMA models, revealing a conserved regulatory role of the SMN complex.