Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma
Mercy Akuma, Minjun Kim, Chenxuan Zhu, Ellis Wiljer, Antoine Gaudreau-Lapierre, Leshan D. Patterson, Lars Egevad, Simon Tanguay, Laura Trinkle‐Mulcahy, William L. Stanford, Yasser Riazalhosseini, Ryan Charles Russell
This study identifies pRb as a novel VHL substrate, showing that its hyperstabilization promotes ccRCC tumorigenesis through transcriptional changes.
Cell Death and Disease · Apr 16, 2025Peer-reviewedCancer Biology