Ryan Charles Russell

This paper introduces a refined CRISPR screening protocol to compare cellular responses across multiple stressors, reducing false positives by 40% through fluorescence-based reporters and fixation steps.

This study identifies LOX as a driver of ccRCC progression by sustaining HIF-2α transcription and modulating the tumor microenvironment.

This study uses a Rosella-PLIN2 biosensor to track lipophagy in atherosclerosis, revealing cell-specific differences in lipid metabolism and immunometabolic interactions.

The paper identifies stress-specific autophagy regulators using CRISPR screens, finding unique kinases for ER-phagy and pexophagy.

This study identifies pRb as a novel VHL substrate, showing that its hyperstabilization promotes ccRCC tumorigenesis through transcriptional changes.

This study shows Salmonella Typhimurium inhibits ER-phagy by targeting FAM134B, enhancing its survival and causing intestinal damage in mice.

This study shows ULK1 phosphorylates ATG16L1, enhancing wildtype function but destabilizing the Crohn’s disease-associated mutant, thereby affecting xenophagy.