Yasser Riazalhosseini

A map of RBP-miRNA regulatory connections for deciphering the mechanisms of transcriptome remodeling in cancer

The paper maps regulatory connections between RBPs and miRNAs in cancer, showing RBP-driven regulation contributes to miRNA activity heterogeneity and identifies DDX55 as a key regulator of miR-29-3p.

Lysyl oxidase drives ccRCC progression by coordinating HIF-2α transcription program with tumor microenvironment

This study identifies LOX as a driver of ccRCC progression by sustaining HIF-2α transcription and modulating the tumor microenvironment.

Single-cell gene programs define subtype identity and metastatic trajectories in renal cell carcinoma

This study identifies 59 gene expression programs in RCC that reveal subtype identity and metastatic trajectories, including a metastatic signature linked to poor clinical outcomes.

Semantic fragment representations for coordinate-free analysis of genomics data

The paper introduces LEAF-1, a fragment-level foundation model for genomics data analysis, showing it can classify cell types and detect cancer from sparse datasets and cell-free DNA.

Microbiome diversity, intra-mucosal bacteria and immune integration within normal and asthmatic airway mucosa

The paper examines microbiome diversity and immune interactions in airway mucosa of healthy and asthmatic individuals, finding associations between bacterial counts and immune network eigenvectors.

Loss of VHL-mediated pRb regulation promotes clear cell renal cell carcinoma

This study identifies pRb as a novel VHL substrate, showing that its hyperstabilization promotes ccRCC tumorigenesis through transcriptional changes.

Pan-cancer analysis of mRNA stability for decoding tumour post-transcriptional programs

The paper analyzes mRNA stability across 7760 cancer samples to identify stability changes and factors driving them in tumour development.