NeurosciencebioRxivPreprint
AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans
Faten A. Sayed, Lay Kodama, Joe C. Udeochu…·Li Gan
This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.