Fuying Gao

Large-scale Perturbation of Systems Biology-Derived Genes Reveals Modifiers of HD-associated Transcriptomic Networks and Pathology

The paper uses genetic perturbations to identify modifiers of HD-associated transcriptomic networks and pathology in mice and patient-derived neurons.

Msh3 and Pms1 Set Neuronal CAG-repeat Migration Rate to Drive Selective Striatal and Cortical Pathogenesis in HD Mice

This study identifies Msh3 and Pms1 as genetic drivers of CAG-repeat migration in HD mice, leading to selective striatal and cortical pathogenesis.

Aging Differentially Alters the Transcriptome and Landscape of Chromatin Accessibility in the Male and Female Mouse Hippocampus

This study examines how aging affects the transcriptome and chromatin accessibility in male and female mouse hippocampus, identifying sex-specific changes in gene expression, alternative splicing, and chromatin features.

BAC Transgenic Expression of Human TREM2-R47H Remodels Amyloid Plaques but Unable to Reprogram Plaque-associated Microglial Reactivity in 5xFAD Mice

This study shows that TREM2-R47H reduces amyloid plaques but fails to improve cognitive deficits or microglial reactivity in 5xFAD mice.

Serotonergic modulation of visual neurons in Drosophila melanogaster

This study identifies serotonin receptor expression in Drosophila visual neurons and shows serotonin modulates visual processing through calcium signaling changes.

AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans

This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.

C. elegans granulins promote an age-associated decline in protein homeostasis via lysosomal protease inhibition

This study identifies granulins as regulators of lysosomal protease activity in C. elegans, showing their role in age-related protein homeostasis decline.

Transcriptional profiling of isogenic Friedreich ataxia induced pluripotent stem cell-derived neurons

This study uses isogenic iPSC-derived neurons to analyze the transcriptomic effects of GAA*TTC repeat expansion in Friedreich ataxia and shows partial restoration with HDACi treatment.