David Le

KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss

This study shows that CT-KIBRA repairs synaptic plasticity and memory in tauopathy models by stabilizing PKMζ, without altering tau levels or preventing synapse loss.

A deep-learning-based screening platform in aging-relevant human motor neurons to identify therapeutic compounds for amyotrophic lateral sclerosis

The paper develops a deep learning platform to screen compounds for ALS treatment using age-relevant human motor neurons and identifies NCB-0846 as a potential therapeutic.

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

This study shows that microglial NF-κB signaling drives tau spreading and toxicity in a mouse model of tauopathy, with inhibition reducing tau pathology and cognitive deficits.

AD-linked R47H-TREM2 mutation induces disease-enhancing proinflammatory microglial states in mice and humans

This study identifies R47H-TREM2 mutation-induced proinflammatory microglial states in human AD and tauopathy mice, showing Akt pathway involvement and potential therapeutic targets.

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

This study shows that adult microglia self-renew to restore homeostasis after ablation, with specific maturation programs and spatial organization.