Author

Robert C. Osorio

University of California, San FranciscoORCID 0000-0002-7669-2176Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Manish Kumar AghiiD· 2 shared Aaron DiaziD· 1 shared Alexander F. HaddadiD· 1 shared Alexander J. EhrenbergiD· 1 shared Ankita Sati· 1 shared Atul SahaiD· 1 shared Atul Saha· 1 shared Elaina J. WangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

Manish Kumar AghiORCID

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2 papers

Recent·Most cited

Non-lytic replicating viral delivery of an IL15 superagonist enhances antitumor immunity and extends survival in glioblastoma

Alexander F. Haddad, Atul Saha, Sara Collins, Isabella Lovalvo, Sabraj A. Gill, Megan L. Montoya, Poojan D. Shukla, Jinpyo Hong, Elaina J. Wang, Pavlina Chuntova, Meeki Lad, Robert Osorio, Jia‐Shu Chen, Melissa Sathavipat, Saket Jain, , Manish K. Aghi

This paper demonstrates that a viral vector delivering an IL15 superagonist enhances antitumor immunity and extends survival in glioblastoma models.

Nature Communications · May 19, 2026Peer-reviewedCancer Biology

Developmental Plasticity and Stromal Co-option Shape a Pituitary Neuroendocrine Tumor Transcriptional Continuum

Robert C. Osorio, Jun Yeop Oh, Ankita Sati, Jangham Jung, Alexander J. Ehrenberg, Atul Saha, Meeki Lad, Harmon Khela, Nicole Brennick, Petros Giannikopoulos, William W. Seeley, Lea T. Grinberg, Aaron Diaz, Manish Kumar Aghi

This study uses snRNA-seq and spatial transcriptomics to show PitNETs exhibit transcriptional continuity and originate from different developmental pathways, influenced by stromal interactions.

bioRxiv · Jun 18, 2025 · PreprintCancer Biology