Author

Saket Jain

University of California, San FranciscoORCID 0000-0002-8655-2951Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Manish Kumar AghiiD· 3 shared Isabella LovalvoiD· 2 shared Meeki LadiD· 2 shared Aditya KatewaiD· 1 shared Agnieszka CiesielskaiD· 1 shared Akhil Rajidi· 1 shared Alex R. ChangiD· 1 shared Alexander F. HaddadiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

Manish Kumar AghiORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologyNature CommunicationsPeer-reviewedMay 19, 2026

Non-lytic replicating viral delivery of an IL15 superagonist enhances antitumor immunity and extends survival in glioblastoma

Alexander F. Haddad, Atul Saha, Sara Collins…·Manish K. Aghi

This paper demonstrates that a viral vector delivering an IL15 superagonist enhances antitumor immunity and extends survival in glioblastoma models.

2 citationstop 3%

mousebulk RNA-seq

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ImmunologyNaturePeer-reviewedSep 3, 2025

Dynamic fibroblast-immune interactions shape wound healing after brain injury

Nathan A. Ewing-Crystal, Nicholas M. Mroz, Amara Larpthaveesarp…·Ari B. Molofsky

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

65 citationstop 1%

mousespatial transcriptomics

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Cancer BiologybioRxivPreprintJan 20, 2025

Druggable genome CRISPRi screen in 3D hydrogels reveals regulators of cortactin-driven actin remodeling in invading glioblastoma cells

Mufeng Hu, Anna Weldy, Isabella Lovalvo…·Manish Kumar Aghi

The paper identifies ACP1 and AURKB as regulators of cortactin-driven actin remodeling in glioblastoma invasion using CRISPRi screens in 3D hydrogels.

2 citations

humanCRISPR screen

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