Jeffrey C. Smith

Functional Synaptic Interactions and Inhibitory Circuitry of the PreBötzinger Complex in the Rhythmic Slice

The paper investigates synaptic interactions in the preBotzinger Complex using in vitro recordings, revealing a simplified inhibitory connectome compared to in situ conditions.

Inference technique for the synaptic conductances in rhythmically active networks and application to respiratory central pattern generation circuits

The paper introduces a method to infer synaptic conductances from neuronal recordings and applies it to respiratory CPG circuits in rat brainstem.

Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator

The paper tests and confirms three predictions of a biophysical model of the mammalian respiratory oscillator using optogenetic and pharmacological manipulations in neonatal mouse slices.

Robustness of respiratory rhythm generation across dynamic regimes

This study shows that respiratory rhythm generation remains robust across different dynamic regimes of intrinsic pacemaker properties in a computational model of the respiratory network.

Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model

The paper re-examines the roles of INaP and ICAN in respiratory rhythm generation using a new computational model, finding that ICAN affects amplitude while INaP drives rhythm.