Author

Nicolas Ruggli

University of BernORCID 0000-0002-7679-6290Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:plant (other)· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:differential expression· 1 Organism:multiple species· 1

Frequent Co-Authors

Artur SummerfieldiD· 3 shared Gert ZimmeriD· 3 shared Obdulio García-NicolásiD· 3 shared Lisa Butticaz· 2 shared Robin Avanthay· 2 shared Charaf BenarafaiD· 1 shared Christian J. WenkeriD· 1 shared Elisabeth HeiderichiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

Artur SummerfieldORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Correlates of protection against African swine fever virus identified by a systems immunology approach

Kirill Lotonin, Francisco Brito, Kemal Mehinagic, Obdulio García-Nicolás, Matthias Liniger, Noelle Donzé, Sylvie Python, Stephanie C. Talker, T.C.W. Ploegaert, Nicolas Ruggli, Charaf Benarafa, Artur Summerfield

This study identifies innate and adaptive immune correlates of protection against ASFV using a systems immunology approach in pigs.

eLife · Jun 29, 2026Peer-reviewedImmunology

An RNA replicon vaccine encoding HA and NA prevents shedding of antigen-drifted 2009 pandemic H1N1 influenza virus in the pig model

Obdulio García-Nicolás, Lisa Butticaz, Robin Avanthay, Nicolas Ruggli, Artur Summerfield, Gert Zimmer

This study evaluates an RNA replicon vaccine encoding HA and NA antigens of H1N1 virus in pigs, showing it prevents shedding of antigen-drifted H1N1 and H5N1 viruses.

bioRxiv · Nov 1, 2025 · PreprintMicrobiology

Immunization with a novel RNA replicon vaccine confers long-lasting protection against H5N1 avian influenza virus in 24 bird species

Marianne Stettler, Stefan Hoby, Christian J. Wenker, Fabia Wyss, Elisabeth Heiderich, Lisa Butticaz, Nicolas Ruggli, Karin E. Darpel, Gert Zimmer

bioRxiv · Jan 15, 2025 · PreprintMicrobiology

Intramuscular prime/intranasal boost vaccination to induce sterilizing immunity against influenza A virus infection

Robin Avanthay, Obdulio García-Nicolás, Nicolas Ruggli, Llorenç Grau‐Roma, Ester Párraga Ros, Artur Summerfield, Gert Zimmer

This paper develops an intramuscular prime/intranasal boost vaccination strategy against influenza A virus that achieves sterilizing immunity in pigs by combining a propagation-defective RNA vector with a modified live-attenuated vaccine.

PLoS Pathogens · Aug 8, 2024Peer-reviewedImmunology