Llorenç Grau‐Roma

Tattoo ink induces inflammation in the draining lymph node and impairs the immune response against a COVID-19 vaccine

This study shows tattoo ink causes long-term inflammation in lymph nodes and reduces vaccine efficacy against COVID-19.

Deep learning-based 3D spatial transcriptomics with X-Pression

X-Pression reconstructs 3D expression signatures from volumetric microcomputed tomography data, demonstrating its utility in analyzing vaccine efficacy and viral replication in mouse lungs.

Peste des Petits Ruminants virus virulence is associated with an early inflammatory profile in the tonsils and cell cycle arrest in lymphoid tissue

This study compares immune responses in goats infected with high and low virulent PPRV strains, finding strain-specific differences in early inflammation and lymphocyte suppression.

Fitness adaptations of Japanese encephalitis virus in pigs following vector-free serial passaging

This study shows that serial passaging of JEV in pigs leads to fitness adaptations and amino acid changes, but not increased direct transmission.

Intramuscular prime/intranasal boost vaccination to induce sterilizing immunity against influenza A virus infection

This paper develops an intramuscular prime/intranasal boost vaccination strategy against influenza A virus that achieves sterilizing immunity in pigs by combining a propagation-defective RNA vector with a modified live-attenuated vaccine.

Deep Learning-based Modeling for Preclinical Drug Safety Assessment

This paper introduces TRACE, a deep learning model for automated liver histopathology assessment in preclinical drug safety, achieving higher concordance than pathologists in lesion scoring and dose-response analysis.