Role of the SAF-A SAP domain in X inactivation, transcription, splicing, and cell proliferation
Judith A. Sharp, Emily Sparago, Rachael Thomas, Kaitlyn Alimenti, Wei Wang, Michael D. Blower
This study investigates the role of SAF-A's SAP domain and its serines S14 and S26 in X inactivation, gene expression, splicing, and cell proliferation, finding they are critical for XIST RNA localization and cell proliferation but not gene expression or splicing.
PLoS Genetics · Jun 10, 2025Peer-reviewedCell Biology