Spatial Transcriptomic Signature of Progressive Fibrosis in Human MASLD: Role of Senescence and Metabolic Reprogramming.
Hani Vu, Yuliangzi Sun, Zherui Xiong, Daniel E. Radford‐Smith, Andrew Causer, Christian Maximilian Nefzger, Eoin Daniel O'Sullivan, Matthew J. Watt, Grant A. Ramm, Andrew Donald Clouston, Katharine M. Irvine, Quan Hoang Nguyen, Elizabeth Ellen Powell
This study uses spatial transcriptomics to analyze liver fibrosis stages in MASLD, identifying metabolic reprogramming and senescence signatures linked to fibrosis progression.
bioRxiv · Mar 20, 2025 · PreprintGenomics