This paper describes a tissue multiplexing method to increase spatial transcriptomics output from limited pathology specimens by combining multiple tissues on a single capture array.

Frontiers in Medicine · Apr 9, 2026Peer-reviewedGenetic & Genomic Medicine

Spatial pharmaco-multiomics reveals drug distribution, metabolic niches, and spatially constrained resistance in medulloblastoma

Tuan Vo, Cedric S. Cui, Aitor Benedicto, Yibi Chen, Andrew Causer, Xiao Tan, Eun Ju Kim, Hani Vu, Anying Xiong, Mark P. Hodson, Yak Deng, Ana Maria Romero Jimenez, Ning Liu, Brett R. Hamilton, Thomas Robertson, , Quan Hoang Nguyen

This study develops a spatial pharmaco-multiomics framework to map drug distribution, metabolic niches, and resistance mechanisms in medulloblastoma using integrated spatial and transcriptomic data.

bioRxiv · Jan 27, 2026 · PreprintCancer Biology

Spatial analysis of HPV associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cancer progression

Gianna Louise Pavilion, Hani Vu, Zherui Xiong, Thi Viet Trinh Dang, Blake O’Brien, Michael D. Walsh, Andrew Causer, Janin Chandra, Quan Hoang Nguyen, Ian Hector Frazer

The paper analyzes spatial immune signatures in HPV-associated cervical tissues to identify immune modulation patterns linked to cancer progression.

The Journal of Pathology · Dec 9, 2025Peer-reviewedGenomics

Integrating 12 Spatial and Single Cell Technologies to Characterise Tumour Neighbourhoods and Cellular Interactions in three Skin Cancer Types

P. Prakrithi, Laura F. Grice, Feng Zhang, Levi Hockey, Samuel X. Tan, Xiao Tan, Zherui Xiong, Onkar Mulay, Andrew Causer, Andrew Newman, Duy Pham, Guiyan Ni, Zewen Kelvin Tuong, Xinnan Jin, Eun Ju Kim, , Quan Hoang Nguyen

The paper integrates 12 spatial and single-cell technologies to analyze cellular interactions and signatures in three skin cancers, identifying key therapeutic targets and genetic associations.

bioRxiv · Jul 25, 2025 · PreprintCancer Biology

Spatial Transcriptomic Signature of Progressive Fibrosis in Human MASLD: Role of Senescence and Metabolic Reprogramming.

Hani Vu, Yuliangzi Sun, Zherui Xiong, Daniel E. Radford‐Smith, Andrew Causer, Christian Maximilian Nefzger, Eoin Daniel O'Sullivan, Matthew J. Watt, Grant A. Ramm, Andrew Donald Clouston, Katharine M. Irvine, Quan Hoang Nguyen, Elizabeth Ellen Powell

This study uses spatial transcriptomics to analyze liver fibrosis stages in MASLD, identifying metabolic reprogramming and senescence signatures linked to fibrosis progression.

bioRxiv · Mar 20, 2025 · PreprintGenomics