Zherui Xiong

This study shows that CEP55 promotes tumorigenesis in cancer models and its deletion suppresses tumor growth and improves survival, especially in PTEN-deficient cancers.

This study shows that myeloid HDAC7 promotes liver inflammation and glucose dysregulation in obesity, using mouse models and human data.

The paper identifies 354,937 novel lncRNAs across 13 cancer types using single-cell and spatial transcriptomics, revealing their cell-type specificity, spatial distribution, and potential functional roles.

STimage predicts gene expression and classifies cell types from histopathological images, improving robustness and interpretability for cancer and disease analysis.

The paper analyzes spatial immune signatures in HPV-associated cervical tissues to identify immune modulation patterns linked to cancer progression.

The paper integrates 12 spatial and single-cell technologies to analyze cellular interactions and signatures in three skin cancers, identifying key therapeutic targets and genetic associations.

This study shows that CASP1 self-cleavage terminates its activity in vivo, maintaining homeostasis and preventing inflammasome-driven diseases.

This study uses spatial transcriptomics to analyze liver fibrosis stages in MASLD, identifying metabolic reprogramming and senescence signatures linked to fibrosis progression.

The paper develops MMCCI, a computational pipeline to integrate cell-cell interaction results across samples, and applies it to uncover global and condition-specific ligand-receptor interaction patterns in aging brain and melanoma datasets.