Christian Maximilian Nefzger

This study uses spatial transcriptomics to analyze liver fibrosis stages in MASLD, identifying metabolic reprogramming and senescence signatures linked to fibrosis progression.

This study shows that c-Src is essential for neovascular tuft formation in Oxygen-Induced Retinopathy, as its depletion reduces tuft formation without affecting cell death, proliferation, or adhesion.

The paper develops MMCCI, a computational pipeline to integrate cell-cell interaction results across samples, and applies it to uncover global and condition-specific ligand-receptor interaction patterns in aging brain and melanoma datasets.

The paper identifies retrotransposon insertions as the main source of mutations in mouse induced pluripotent stem cells, showing hypomethylation of LINE-1 elements and their impact on gene regulation.

This study introduces UnTANGLeD, an unsupervised method that organizes genes into programs based on gene-trait associations, revealing 173 clusters with distinct biological functions and disease relevance.

The paper reports the generation of four iPSC lines from PBMCs of an ADHD patient and their healthy sibling, confirming pluripotency and differentiation potential.

This paper develops a modular dCas9-SunTag DNMT3A system to improve DNA methylation editing specificity and reduce off-target effects compared to direct fusion constructs.