This study shows that CEP55 promotes tumorigenesis in cancer models and its deletion suppresses tumor growth and improves survival, especially in PTEN-deficient cancers.

Advanced Science · Aug 10, 2026Peer-reviewedCancer Biology

SpaMTP: Integrative Statistical Analysis and Visualisation of Spatial Metabolomics and Transcriptomics data.

Andrew Causer, Tianyao Lu, Jurgen Kriel, Joel J D Moffet, Christopher C. J. Fitzgerald, Andrew Newman, Hani Vu, Xiao Tan, Tuan Vo, Cedric S. Cui, Vinod K. Narayana, James Richard Whittle, Sarah A. Best, Saskia Freytag, Quan Hoang Nguyen

SpaMTP integrates spatial metabolomics and transcriptomics data through a comprehensive analysis pipeline and visualization tools.

Nature Methods · Jul 31, 2026Peer-reviewedBioinformatics

Unraveling lncRNA Diversity at a Single Cell Resolution and in a Spatial Context across Different Cancer Types

P. Prakrithi, Tuan Vo, Zherui Xiong, Hani Vu, Loan T Nguyen, Andrew Newman, Julie Wilhelmey, Vicki Whitehall, Jazmina L. Gonzalez Cruz, Simon Wood, Andrew John Mallett, Ishaan Gupta, Quan Hoang Nguyen

The paper identifies 354,937 novel lncRNAs across 13 cancer types using single-cell and spatial transcriptomics, revealing their cell-type specificity, spatial distribution, and potential functional roles.

Nature Methods · May 14, 2026Peer-reviewedCancer Biology

Spatial pharmaco-multiomics reveals drug distribution, metabolic niches, and spatially constrained resistance in medulloblastoma

Tuan Vo, Cedric S. Cui, Aitor Benedicto, Yibi Chen, Andrew Causer, Xiao Tan, Eun Ju Kim, Hani Vu, Anying Xiong, Mark P. Hodson, Yak Deng, Ana Maria Romero Jimenez, Ning Liu, Brett R. Hamilton, Thomas Robertson, , Quan Hoang Nguyen

This study develops a spatial pharmaco-multiomics framework to map drug distribution, metabolic niches, and resistance mechanisms in medulloblastoma using integrated spatial and transcriptomic data.

bioRxiv · Jan 27, 2026 · PreprintCancer Biology

Spatial analysis of HPV associated cervical intraepithelial neoplastic tissues demonstrate distinct immune signatures associated with cervical cancer progression

Gianna Louise Pavilion, Hani Vu, Zherui Xiong, Thi Viet Trinh Dang, Blake O’Brien, Michael D. Walsh, Andrew Causer, Janin Chandra, Quan Hoang Nguyen, Ian Hector Frazer

The paper analyzes spatial immune signatures in HPV-associated cervical tissues to identify immune modulation patterns linked to cancer progression.

The Journal of Pathology · Dec 9, 2025Peer-reviewedGenomics

Integrating 12 Spatial and Single Cell Technologies to Characterise Tumour Neighbourhoods and Cellular Interactions in three Skin Cancer Types

P. Prakrithi, Laura F. Grice, Feng Zhang, Levi Hockey, Samuel X. Tan, Xiao Tan, Zherui Xiong, Onkar Mulay, Andrew Causer, Andrew Newman, Duy Pham, Guiyan Ni, Zewen Kelvin Tuong, Xinnan Jin, Eun Ju Kim, , Quan Hoang Nguyen

The paper integrates 12 spatial and single-cell technologies to analyze cellular interactions and signatures in three skin cancers, identifying key therapeutic targets and genetic associations.

bioRxiv · Jul 25, 2025 · PreprintCancer Biology

Spatial Transcriptomic Signature of Progressive Fibrosis in Human MASLD: Role of Senescence and Metabolic Reprogramming.

Hani Vu, Yuliangzi Sun, Zherui Xiong, Daniel E. Radford‐Smith, Andrew Causer, Christian Maximilian Nefzger, Eoin Daniel O'Sullivan, Matthew J. Watt, Grant A. Ramm, Andrew Donald Clouston, Katharine M. Irvine, Quan Hoang Nguyen, Elizabeth Ellen Powell

This study uses spatial transcriptomics to analyze liver fibrosis stages in MASLD, identifying metabolic reprogramming and senescence signatures linked to fibrosis progression.

bioRxiv · Mar 20, 2025 · PreprintGenomics