Structure and Function of TM6SF1 Reveal Role in mTORC1 Signaling
Sen Hong, Liangjie Jia, Rong Wang, Nadia Elghobashi‐Meinhardt, Helen H. Hobbs, Xiaochun Li
This study determines the cryo-EM structure of TM6SF1 and shows it regulates mTORC1 signaling through cholesterol-dependent interaction with LAMTOR1, affecting TFEB activation.
Proceedings of the National Academy of Sciences · Sep 14, 2026Peer-reviewedCell Biology